Endocrine Abstracts

Glucocorticoids (GC) are powerful metabolic hormones with anti-inflammatory effects. Exogenous GC are in wide therapeutic use but often cardio-metabolic side effects are limiting and resistance may develop. GC act via a nuclear hormone receptor (GR), which is a ligand activated transcription factor. GR binds DNA at sites distant from target gene promoters such as enhancers. Macrophages are ubiquitous innate immune cells that are major targets of GC and have roles in normal dev...